Turned-Off Cannabinoid Receptor Turns on Colorectal Tumor Growth
HOUSTON, Aug. 1, 2008 – New preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing role in human colorectal cancer, scientists report in the Aug. 1 edition of the journal Cancer Research. CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for [...]
Medical marijuana uses – 700 medical marijuana clinical studies and papers
700 uses of Medical Marijuana | Sorted by Disease | ADD – Wilson’s Disease | Links to 700 Clinical Studies | Medical Marijuana Reference | Cannabis as Medicine Medical marijuana and cannabis studies A collection of clinical studies, papers and reference providing the ultimate resource for medical disorders helped by medical marijuana. ADD/ [...]
Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo
Nicholas A. Jones, Andrew J. Hill, Imogen Smith, Sarah A. Bevan, Claire M. Williams, Benjamin J. Whalley and Gary J. Stephens + Author Affiliations School of Pharmacy (N.A.J., A.J.H., I.S., S.A.B., B.J.W., G.J.S.) and School of Psychology (N.A.J., A.J.H., C.M.W.), University of Reading, Whiteknights, Reading, United Kingdom Address correspondence to: Dr. Gary Stephens, School of [...]
Cannabindiol
CBD (cannabidiol) – Cannabidiol is the cannabinoid obtaining most recent mainstream exposure for its multitude of benefits with non-psychoactive effects. Unites States Patent #6,630,507 – Hampson, et al. found cannabinoids (specifically CBD) effective as antioxidants & neuroprotectants without providing any psychoactive effects. Neuroprotective antioxidant more potent than ascorbate or topopherol with ability to pass the [...]
Similar Readily Cannabinoids Penetrate into the Brain
The pharmacokinetics (behaviour of a substance in the body) of cannabidiol (CBD), cannabidivarine (CBDV), delta-9- tetrahydrocannabivarin (delta-9-THCV) and cannabigerol (CBG) in mice and rats were investigated at the University of Aberdeen, UK. Researchers determined concentrations in the brain after intraperitoneal (injection into the abdomen) and oral administration. The effects of CBD were further investigated in [...]
Cannabindiol Crosses the Blood Brain Barrier
11/08/08 Dr. Courtney speaks on the CANNABIS ISSUES PANEL of experts and authors at the 18th ANNUAL SOUTHERN HUMBOLDT HEMP FEST Emcee: Jimmy Durchslag: Next we have William Courtney, DR. BILL COURTNEY, Cannabis Medical Consultant. Many of you… I know he’s based in Mendocino, has an office in Willits, but he’s also here in our [...]
The Human Endocannabinoid System
The Endocannabinoid System (ECS) started revealing itself to researchers in the 1940s and by the late ‘60s the basic structure and functionality had been laid out. Today we know the ECS is a comprehensive system of biochemical modulators that maintain homeostasis in all body systems including the central and peripheral nervous systems, all organ systems, [...]
THC and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism
Peter M. Zygmunt, David A. Andersson, and Edward D. Högestätt + Author Affiliations 1 Department of Clinical Pharmacology, Institute of Laboratory Medicine, Lund University Hospital, SE-221 85 Lund, Sweden Abstract Although Δ9-tetrahydrocannabinol (THC) produces analgesia, its effects on nociceptive primary afferents are unknown. These neurons participate not only in pain signaling but also in the [...]
Science/Human: Synthetic cannabinoid improves survival after severe brain injury in clinical study
In a clinical study with 97 comatose patients a synthetic cannabinoid (named KN38-7271) improved survival in the acute early phase after a head injury. The trial was conducted in 14 EURopean neurosurgical centres. KN38-7271 binds both to the CB1 and the CB2 receptor, similar to THC and some other cannabinoids. Participants received 1 or 0.5 mg [...]
