Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress.

By | Aug 28, 2012

The molecular constituents of endocannabinoid (eCB) signaling are abundantly expressed within the mammalian amygdaloid complex, consistent with the robust role of eCB signaling in the modulation of emotional behavior, learning, and stress-response physiology. Here, we detail the anatomical distribution of eCB signaling machinery in the amygdala and the role of this system in the modulation [...]

Pot lowers chronic pain even without the high: Study

By | Aug 27, 2012

The new study, the first clinical trial in the world to allow patients to take marijuana home with them and “self-dose,” found that for people with neuropathic pain — a common and dreaded condition that causes electric, stabbing pain — smoking cannabis reduced pain, improved mood and helped them sleep. Photograph by: Leon Neal , [...]

Does marijuana really relieve pain?

By | Aug 27, 2012

Absent from much of the debate so far, however, is scientific evidence to establish whether marijuana really works to relieve chronic pain; and if it does, whether it does so in a manner that is distinct from simply providing the well-known high that has made it a popular recreational but illicit drug. Photograph by: Christopher [...]

Cannabindiol: United States Patent 6,630,507

By | Aug 25, 2012

United States Patent 6,630,507 Hampson ,   et al. October 7, 2003 Cannabinoids as antioxidants and neuroprotectants AbstractCannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and [...]

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

By | Aug 24, 2012

Nicholas A. Jones, Andrew J. Hill, Imogen Smith, Sarah A. Bevan, Claire M. Williams, Benjamin J. Whalley and Gary J. Stephens + Author Affiliations School of Pharmacy (N.A.J., A.J.H., I.S., S.A.B., B.J.W., G.J.S.) and School of Psychology (N.A.J., A.J.H., C.M.W.), University of Reading, Whiteknights, Reading, United Kingdom Address correspondence to: Dr. Gary Stephens, School of [...]

Cannabindiol

By | Aug 24, 2012

CBD (cannabidiol) – Cannabidiol is the cannabinoid obtaining most recent mainstream exposure for its multitude of benefits with non-psychoactive effects. Unites States Patent #6,630,507 – Hampson, et al. found cannabinoids (specifically CBD) effective as antioxidants & neuroprotectants without providing any psychoactive effects. Neuroprotective antioxidant more potent than ascorbate or topopherol with ability to pass the [...]

Similar Readily Cannabinoids Penetrate into the Brain

By | Aug 24, 2012

The pharmacokinetics (behaviour of a substance in the body) of cannabidiol (CBD), cannabidivarine (CBDV), delta-9- tetrahydrocannabivarin (delta-9-THCV) and cannabigerol (CBG) in mice and rats were investigated at the University of Aberdeen, UK. Researchers determined concentrations in the brain after intraperitoneal (injection into the abdomen) and oral administration. The effects of CBD were further investigated in [...]

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